Wolfgang Losert,John T. Fourkas,Meghan Driscoll,Floyd Bates, II,Xiaoyu Sun,Can Guven,Joshua Parker
申请号：
US15420016
公开号：
US20170216479A1
申请日:
2017.01.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides method of guiding unidirectional movement of a cell comprising exposing the cell to a surface comprising an asymmetric, three-dimensional pattern of one or a plurality of topographical elements for a time period sufficient to bias actin polymerization within the cell. The invention also provides methods of inducing directional movement of a cell, and methods of harnessing an actin wave within a cell. In addition, the invention provides compositions comprising a contact side, wherein at least a portion of the contact side comprises a cell contact portion comprising an asymmetric, three-dimensional pattern of one or a plurality of topographical elements, and methods of inducing healing of a wound of a subject comprising contacting the wound with the composition.
