Vijaykumar Reddy RAJASEKHAR,Brendan Mark JOHNSON,David B. MACLEAN,Lynn SEELY,Paul N. MUDD, JR.
申请号：
MX2019003733
公开号：
MX2019003733A
申请日:
2017.09.29
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
Methods for treating prostate cancer, including advanced prostate cancer, in a subject in need thereof, include administering once-daily to the subject, at least 80 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-met hoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyr imidin-6-yl)phenyl)-N'-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof. Another method includes: administering once-daily to the subject in need thereof, an oral load dose formulation having from 240 mg to 480 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-met hoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyr imidin-6-yl)phenyl)-N'-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof； and thereafter administering once-daily to the subject, an oral maintenance dose formulation having 80 mg to 160 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethyiamino)methyl)-3-(6-met hoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyr imidin-6-yl)phenyl)-N'-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof.Metodos de tratamiento de cancer de prostata, que incluyen cancer de prostata avanzado, en un sujeto que lo necesita, que comprenden administrar una vez al dia a dicho sujeto, por lo menos 80 mg de N-(4-(1-(2,6-difluorobencil)-5-((dimetilamino)metil )-3-(6-metoxi-3- piridazinil)-2,4-dioxo-1,2,3,4-tetrahidrotien[2,3 -d]pirimidin-6-il)fenil)-N'-metoxiurea o una cantidad correspondiente de una sal farmaceuticamente aceptable de la misma； otro metodo incluye: administrar una vez al dia a dicho sujeto que lo necesita, una formulacion de una dosis de carga oral que comprende entre 240 mg y 480 mg de N-(4-(1-(2,6-difluorob encil)-5- ((dimetilamino)metil)-3-(6-metoxi-3-piridazinil)-2,4-dio xo-1,2,3,4-tetrahidrotien[2,3-d]pirimidin-6- il)fenil)-N'-metoxiur ea, o una cantidad correspondiente de una sal farmaceuticamente aceptable de la misma； y de all
