Case comprises: a first container comprising hyaluronic acid or its derivatives having molecular weight of 10 5>;-3x 10 6>;Daltons, preferably 8x 10 5>;-1.5x 10 6>;Daltons with a final mass percentage of hyaluronic acid formulation or one of its derivatives (0.001-90%, preferably 0.05-10%) and a food grade excipient or excipient; and a second container comprising an active substance and a preservative with a final mass percentage of 0.0001-5%. ACTIVITY : Ophthalmological; Tranquilizer. MECHANISM OF ACTION : None given.