JEAN-MARC PLANCHER,RAINER E. MARTIN,STEPHEN M. LYNCH,TANJA SCHULZ-GASCH,WERNER NEIDHART
申请号：
BR112015012885
公开号：
BR112015012885A2
申请日:
2013.11.29
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease.
