METHODE DE TRAITEMENT OU D'AMELIORATION DES TROUBLES METABOLIQUES A L'AIDE DE PROTEINES DE LIAISON ANTAGONISTES POUR PROTEINES DE FUSION AGONISTES DU RECEPTEUR DU PEPTIDE INHIBITEUR GASTRIQUE (GIPR)/RECEPTEUR GLP-1
WALKER, KENNETH W.,HOLDER, JERRY RYAN,LLOYD, DAVID J.,LU, SHU-CHEN,VENIANT-ELLISON, MURIELLE M.,STANISLAUS, SHANAKA
申请号：
CA3066251
公开号：
CA3066251A1
申请日:
2018.06.20
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Method of treating metabolic diseases and disorders using a composition comprising a GLP-l/GIPR antigen binding protein fusion protein are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises the C-terminus of a GLP-1 analog fused to the N-terminus of the light chain variable or heavy chain variable region of an antibody or functional fragment thereof that binds GIPR, optionally with a linker in between.
