TRIAZOLES SUBSTITUES PAR ARYLE POLYCYCLIQUE ET TRIAZOLES SUBSTITUES PAR HETEROARYLE POLYCYCLIQUE UTILES COMME INHIBITEURS D'AXL

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专利权人:

RIGEL PHARMACEUTICALS; INC.

发明人:

GOFF, DANE,ZHANG, JING,SINGH, RAJINDER,HOLLAND, SACHA,YU, JIAXIN,HECKRODT, THILO,DING, PINGYU,LITVAK, JOANE

申请号：

CA2704052

公开号：

CA2704052C

申请日:

2007.12.29

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

There is described compounds of formula (l):(see formula I)wherein: R1, R4 and R5 are independently selected from hydrogen, alkyl, aryl,aralkyl, -C(O)R9or -C(O)N(R6)R7； and R2 and R3 have prescribed meanings. The subjectpolycyclic aryl andpolycyclic heteroaryl substituted triazoles and pharmaceutical compositionscontaining thesecompounds can be used in inhibiting the activity of the receptor proteintyrosine kinase Axl. Useof these compounds in treating diseases or conditions associated with Axlcatalytic activity arealso disclosed.

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