University of Tennessee Research Foundation;Gtx; Inc.;Gtx, Inc.
发明人:
NARAYANAN, Ramesh,MILLER, Duane D.,PONNUSAMY, Thamarai,HWANG, Dong-Jin,HE, Yali,PAGADALA, Jayaprakash,DUKE, Charles B.,COSS, Christopher C.,DALTON, James T.
申请号：
EP16783866
公开号：
EP3286164A4
申请日:
2016.04.21
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
