Laboratoire Français du Fractionnement et des Biotechnologies
发明人:
PLANTIER, Jean-Luc
申请号：
EP14708609.4
公开号：
EP2951297B1
申请日:
2014.02.03
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention concerns a protein comprising a mutated sequence of SEQ ID No. 1, said mutated sequence of SEQ ID No. 1 comprising at least one mutation A, A&prime, B, C or C&prime, in which: mutation A consists of substituting amino acids 43 to 52 of sequence SEQ ID No. 1 with a sequence chosen from DFLAEGLTPR, KATN*ATLSPR and KATXATLSPR, mutation A&prime consists of substituting amino acids 47 to 52 of sequence SEQ ID No. 1 with a sequence chosen from TSKLTR, FNDFTR, LSSMTR, PPSLTR and LSCGQR, mutation B consists of inserting a sequence chosen from DFLAEGLTPR, KATN*ATLSPR, KATXATLSPR, TSKLTR, FNDFTR, LSSMTR, PPSLTR and LSCGQR, between amino acids 52 and 53 of sequence SEQ ID No. 1, mutation C consists of inserting a sequence chosen from DFLAEGLTPR, KATN*ATLSPR and KATXATLSPR, between amino acids 52 and 53 of sequence SEQ ID No. 1, and of deleting amino acids 4 to 13 from sequence SEQ ID No. 1, mutation C&prime consists of inserting a sequence chosen from TSKLTR, FNDFTR, LSSMTR, PPSLTR and LSCGQR, between amino acids 52 and 53 of sequence SEQ ID No. 1, and of deleting amino acids 4 to 9 from sequence SEQ ID No. 1.
