PEPTIDE INHIBITORS OF HCV NS3/4A PROTEASE COMPRISING NON-PROTEINOGENIC AMINO RESIDUES

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专利权人:

King Abdulaziz University

发明人:

Moustafa E. EL-ARABY,Abdelsattar Mansour Omar,Mahmoud Abdelkhalek El- Faky,Sameh Hamdy Abdelmageed Soror,Maan Talaat Khayat,Hani Zakariah Asfour,Faida Hassan Bamane

申请号：

US16371610

公开号：

US20200308228A1

申请日:

2019.04.01

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Peptide inhibitors of activation of hepatitis C virus (HCV) NS3 protease are disclosed. They are analogs of the activation peptide HCV NS4 of residues 21-33 of SEQ ID NO: 2 and contain non-proteinogenic amino acids. Competitive binding studies showed the peptide analogs bind HCV NS3 protease at the activation site.

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