MITROPHANOUS, KYRIACOS,RALPH, SCOTT,STEWART, HANNAH,KINGSMAN, ALAN
申请号：
CA3052407
公开号：
CA3052407A1
申请日:
2012.10.26
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides a construct comprising (i) a nucleotidesequence whichencodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodesGTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodesAromatic Amino AcidDopa Decarboxylase (AADC) wherein the nucleotide sequence encoding TH islinked to thenucleotide sequence encoding CH1 such that they encode a fusion protein TH-CH1.The invention also provides a viral vector comprising such a nucleotidesequence and its usein the treatment and/or prevention of Parkinson's disease.
