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CONSTRUCTION
专利权人:
OXFORD BIOMEDICA (UK) LIMITED
发明人:
MITROPHANOUS, KYRIACOS,RALPH, SCOTT,STEWART, HANNAH,KINGSMAN, ALAN
申请号:
CA3052407
公开号:
CA3052407A1
申请日:
2012.10.26
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The present invention provides a construct comprising (i) a nucleotidesequence whichencodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodesGTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodesAromatic Amino AcidDopa Decarboxylase (AADC) wherein the nucleotide sequence encoding TH islinked to thenucleotide sequence encoding CH1 such that they encode a fusion protein TH-CH1.The invention also provides a viral vector comprising such a nucleotidesequence and its usein the treatment and/or prevention of Parkinson's disease.
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