A power injector (40) includes a movable ram (74) operable to interface with and move a plunger (90a/b) of a syringe (86a/b). The power injector (40) may be operable to automatically determine a proper home position for the particular type of syringe (86a/b) to be used in a fluid injection sequence. The power injector (40) may also include ram homing logic (182) operable to automatically move the ram (74) to a home position after an injection. Such automatic homing of the ram (74) may, for example, be initiated by the end of an injection sequence in preparation for another injection sequence, by the opening of a faceplate (102a/b), by a user input, or by any combination thereof.