The present invention relates to novel benzohydroxamic compounds of formula (I) and (II) and pharmaceutically acceptable salts, isomers and prodrugs thereof, exhibiting a high selective inhibitory activity against histone deacetylase 6 (HDAC6) enzyme.La presente invención se refiere a nuevos compuestos benzohidroxámicos de fórmula (I) y (II) y sus sales, isómeros y profármacos farmacéuticamente aceptables, que exhiben una actividad inhibitoria selectiva contra la enzima histona desacetilasa 6 (HDAC6). (ver fórmula).