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Method for deriving melanocytes from the hair follicle outer root sheath and preparation for grafting
专利权人:
UNIVERSITÄT LEIPZIG
发明人:
SAVKOVIC VUK,DIECKMANN CHRISTINA,SIMON JAN-CHRISTOPH,SCHULZ-SIEGMUND MICHAELA,HACKER MICHAEL
申请号:
NZ62396612
公开号:
NZ623966A
申请日:
2012.10.29
申请国别(地区):
NZ
年份:
2016
代理人:
摘要:
A method for generating melanocytes from stem cells comprising the steps of: (i) removing the bulb of an epilated human hair; (ii) incubating the remaining part of the epilated hair with a collagen degrading agent to separate stem cells from the outer root sheath; (iii) cultivating the separated stem cells from step (ii) in a medium that induces differentiation and stimulates growth of stem cells, melanocyte precursors and melanocytes, wherein the medium comprises one or more growth factors for differentiation into melanotic melanocytes. Furthermore, a method for producing an autograft, a homograft or an allograft comprising melanocytes is disclosed herein as well as autografts, a homografts and allografts or melanocytes for the treatment of diseases related to depigmentation of the skin or for the treatment of scars.
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