Serengulam V. Govindan,William J. McBride,Nalini Sathyanarayan,Christine Mazza-Ferreira,David M. Goldenberg
申请号：
US14492312
公开号：
US20150018516A1
申请日:
2014.09.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed are methods, compositions and uses of conjugates of prodrug forms of 2-pyrrolinodoxorubicin (P2PDox) with antibodies or antigen-binding fragments thereof (ADCs), with targetable construct peptides or with other targeting molecules that are capable of delivering the P2PDox to a targeted cell, tissue or pathogen. Once delivered to the target cell, the ADC or peptide conjugate is internalized, a highly toxic 2-pyrrolinodoxorubicin (2-PDox) is released intracellularly. The P2PDox-peptide or ADC conjugates are of use to treat a wide variety of diseases, such as cancer, autoimmune disease or infectious disease.
