HERMANN GRAM,PHIL LOWE,THOMAS JUNG,TIMOTHY WRIGHT,TREVOR MUNDEL
申请号：
PT06826560
公开号：
PT1940465E
申请日:
2006.10.24
申请国别(地区):
PT
年份:
2012
代理人:
摘要：
This disclosure relates to a novel use of IL-1²-ligand/IL-1 receptor disrupting compounds (herein referred to as "IL-1 beta Compounds") such as small molecular compounds disrupting IL-1² ligand - IL-1 receptor interaction, IL-1² antibodies or IL-1 receptor antibodies, e.g. IL-1² binding molecules described herein, e.g. antibodies disclosed herein, e.g. IL-1² binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1² ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.
