Elizabeth Brooke Hutchinson,Mary Elizabeth Meyerand,Paul Anthony Rutecki,Thomas Peter Sutula
申请号：
US13198376
公开号：
US20120065150A1
申请日:
2011.08.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention provides methods for reducing the extent and progression of traumatic brain injury and its deleterious sequellae specifically cognitive decline, post-traumatic epilepsy, post-traumatic stress disorder, and other adverse consequences depending on the progression of the initial injury, comprising administering to a TBI victim in need thereof a therapeutically-effective amount of an antiglycolytic compound, particularly 2-deoxyglucose (2-DG) or glycolysis-inhibiting analogs thereof. The invention also provides pharmaceutical compositions of 2-DG or glycolysis-inhibiting analogs thereof for use in the methods of the invention.
