SYSTEME ET METHODE DE SILENCEUR DE GENE PHOTO CONTROLE REVERSIBLE

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专利权人:

UNIVERSITY OF ONTARIO INSTITUTE OF TECHNOLOGY

发明人:

DESAULNIERS, JEAN-PAUL,HAMMILL, MATTHEW

申请号：

CA3006670

公开号：

CA3006670A1

申请日:

2018.05.30

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

In one aspect, a chemically-modified siRNA for reversible photo-controlledgenesilencing is provided. In one embodiment, one or more nucleotides the sensestrand of the siRNA are replaced with a spacer comprising an azobenzene orderivative thereof. The azobenzene or derivative thereof undergoesisomerizationbetween the trans-configuration and the cis-configuration in the presence oflightfrom a light source and the siRNA optionally has higher RNA silencing activitywhen the azobenzene or derivative thereof is in the trans-configurationcomparedto the cis-configuration. In other aspects, the chemically-modified siRNAsmay,for example, be useful as both therapeutics and research tools.

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