This invention relates to novel substituted triazolo-pyridazines, their derivatives, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an ±1 -GABA-A receptor antagonist and/or a ±2, ±3 and ±5 GABA-A receptor agonist.