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POLY-(LACTIDE/GLYCOLIDE) A EFFET DE LIBERATION IMMEDIATE REDUIT
专利权人:
INC.;QLT USA
发明人:
DADEY, ERIC,MIDDLETON, JOHN,NORTON, RICHARD L.
申请号:
CA2678350
公开号:
CA2678350C
申请日:
2008.02.13
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
A controlled-release formulation comprising a flowable delivery system, a water-soluble organic solvent and a bioactive agent. The delivery system comprises a biocompatible, biodegradable, non-hydrolyzed linear poly(lactide-glycolide) (PLG) low-burst copolymer material having a weight average molecular weight of 10 to 50 kDa and a polydispersity index of 1.4 to 2Ø The PLG low-burst copolymer material does not include a linear copolymer fraction that is characterized by a weight average molecular weight of 4 to 10 kDa and a polydispersity index of 1.4 to 2.5. A method for the preparation of the PLG low-burst copolymer material is provided. Uses of the formulation are provided.
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http://www.ckcest.cn/home/

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