The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives including (i) protocatechuic acid and its derivatives, (ii) 3,4-dihydroxycinnamic acid with its trans isomer or caffeic acid and its derivatives, especially hydrocaffeic acid, rosmarinic acid, chlorogenic acid and caffeic acid phenethyl ester, and with its cis-isomer and its derivatives, especially esculin, (iii) dihydroxyphenylglycol, and (iv) members of the flavonoid familly such as taxifolin and fustin (dihydroflavonols), fisetin (a flavonol), eriodictyol (a flavanone), , with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5) obtained from a culture of Leuconostoc species, and more particularly from the culture of Leuconostoc mesenteroides NRRL B-512F. These O-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrhytmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic antimutagenic, antineoplastic, anti-thrombotic, and vasodilatory formulations, or in any other field of application. All the more, glucosylated phenolics derivatives objects of the invention can be hydrolyzed by the human natural microbiotes, thus releasing the active part of the phenolic compound upon time during their usage or by an ±-glucosidase (EC 3.2.1.20).본 발명은 피로카테콜(pyrocatechol) 또는 슈크로오스(sucrose)의 글루코오스 부분(glucose moiety)을 이용한 그것의 유도체 중에 선택되는 효소 농도(enzymatic condensation)에 의한 페놀화합물 유도체의 제조에 관한 것이다. 상기 페놀화합물의 생성은 글루코실트랜스퍼라아제(glucosyltransferase, EC 2.4.1.5)를 사용하여 수행할 수 있다. 이들 선택된 페놀화합물의 O-α-글루코시드는 신규하며, 물에서의 용해도가 그들의 출처인 페놀화합물(parent polyphenol)에 비하
