RAVINDRA B. UPASANI,BENNY C. ASKEW,BOYD L. HARRISON,FRANCESCO G. SALITURO,ALBERT J. ROBICHAUD
申请号:
PT12781534
公开号:
PT2766380T
申请日:
2012.10.12
申请国别(地区):
PT
年份:
2019
代理人:
摘要:
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I):where R<;sup>;1<;/sup>;, R<;sup>;2<;/sup>;, R<;sup>;3<;/sup>;, R<;sup>;3'<;/sup>;, R<;sup>;4<;/sup>;, R<;sup>;6a<;/sup>;, R<;sup>;6a<;/sup>;, R<;sup>;11a<;/sup>;, and R<;sup>;11b<;/sup>;are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, insomnia, anxiety, depression, traumatic brain injury (TBI), stress, and epilepsy.