Provided herein are PAK inhibitors and methods of utilizing PAK inhibitors for the treatment of CNS disorders such as neuropsychiatric disorders or neurofibromatosis. Also described herein are methods of utilizing PAK inhibitors for the treatment of cancer.本文提供PAK抑制劑及使用PAK抑制劑以治療諸如神經精神病症或神經纖維瘤病之CNS病症之方法。本文也描述使用PAK抑制劑以治療癌症之方法。