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BIOLOGICAL METHOD FOR IN VIVO TRACKING OF MOLECULES AFFECTING CELLULAR MIGRATION
专利权人:
发明人:
ALLENDE CONNELLY MIGUEL
申请号:
IN7756/DELNP/2010
公开号:
IN2010DN07756A
申请日:
2010.11.02
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
Cellular migration is a normal part of the normal development of the human being and, in certain pathologies, its alteration damages physiological performance, so that it is necessary to leam about its molecular and cellular foundations and establish methodologies to identify those molecules that modulate this cellular behavior. A screening method using zebra fish embryos is used to follow the advance in the migration of the lateral line primordium upon contact with a test compound. Modulators found are Fenritinide, PGD2 and is-deoxy-PJE2. The invention refers to a biological method for the IN VIVO, fast, massive and simultaneous tracking of molecules capable of affecting cellular migration, in order to facilitate the finding of potential candidates to be used in the diagnosis, prevention, and, principally, for the preparation of pharmaceutical compositions for the treatment of congenital pathologies, immune system dysfunctions, tissue regeneration failure, inflammation, cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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