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ANTI-BACTERIAL SIDEROPHORE-AMINOPENICILLIN CONJUGATES
专利权人:
发明人:
申请号:
EP13882608.6
公开号:
EP2986617A4
申请日:
2013.10.23
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
An artificial tris-catecolate siderophore with a tripodal backbone and its conjugates with ampicillin and amoxicillin were synthesized. Both conjugates exhibited significantly enhanced in vitro antibacterial activities against Gram-negative species compared to the parent drugs, especially against P. aeruginosa. The conjugates appear to be assimilated by an induced bacterial iron transport process as their activities were inversely related to iron concentration. The easily synthesized tris-catecolate siderophores can be used with a variety of drugs as conjugates to target antibiotic-resistant Gram-negative bacteria.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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