Richard Rox Anderson,Bernhard Ortel,Eliot F. Battle,Edwin K. Joe
申请号：
US12643089
公开号：
US08207212B2
申请日:
2009.12.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods for preventing damage to the epidermis during PDT induced using a pre-photosensitizing agent are provided. The methods of the present invention utilize spatial confinement to control formation of a photoactive species from a topically-applied pre-photosensitizing agent. In one embodiment, thermal inhibition is used to prevent the metabolism of a pre-photosensitizing agent in epithelial tissue surrounding a treatment site. In another embodiment, a chemical inhibitor can be applied to the epithelial tissue to inhibit the conversion of a pre-photosensitizing agent into a phototoxic species.
