1,3,4-THIADIAZOLIC COMPOUNDS AND ITS USE IN CANCER TREATMENT

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专利权人:

Cancer Research Technology Limited

发明人:

FINLAY, Maurice, Raymond, Verschoyle,PERKINS, David, Robert,NISSINK, Johannes, Wilhelmus, Maria,RAUBO, Piotr, Antoni,SMITH, Peter, Duncan,BAILEY, Andrew

申请号：

DK16805078

公开号：

DK3383872T3

申请日:

2016.11.30

申请国别(地区):

DK

年份:

2020

代理人:

摘要：

A compound of Formula (I) or a pharmaceutically acceptable salt thereof, is described. Q can be pyridazin-3-yl, 6- fluoropyridazin-3-yl； R1 can be H； R2 and R3 can each independently be C1-C6 alkyl, or R2 and R3 taken together are -(CH2)3； or R1 and R2 taken together can be -(CH2)2- and R3 can be -CH3； R4 halo, -CH3, -OCH3, -OCHF2, -OCF3, or -CN； and n can be 0, 1, or 2. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.

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