MODEL ANIMAL FOR FIBROSIS

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专利权人:

InfiCure Bio AB

发明人:

Holmberg Dan

申请号：

US201815917511

公开号：

US2018310535(A1)

申请日:

2018.03.09

申请国别(地区):

美国

年份:

2018

代理人:

摘要：

Disclosed is a non-human animal comprising a genetic construct expressing TCRα and TCRβ genes and wherein the animal comprises a null-mutated Rag-2 locus. Described herein is also a NOD.Rag2−/− mouse expressing a transgenic α,β T cell receptor. The animals spontaneously develop chronic inflammation and fibrosis, and are useful as animal models of fibrotic disease.

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