The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like； A is lower alkylene； Ring X is optionally substituted arylene； E is bond or lower alkenylene； Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group； G is -NH-G<；sub>；2<；/sub>；-, -N(lower alkyl)-G<；sub>；2<；/sub>；-, -NH-CH<；sub>；2<；/sub>；-G<；sub>；2<；/sub>；-, -N(lower alkyl)-CH<；sub>；2<；/sub>；-G<；sub>；2<；/sub>；- or -CH<；sub>；2<；/sub>；-G<；sub>；2<；/sub>；-, [wherein G<；sub>；2<；/sub>； binds to R2, G<；sub>；2<；/sub>；-R2 is bond-R2, phenylene-G<；sub>；3<；/sub>；-R2, phenylene-G<；sub>；4<；/sub>；-O-R2, phenylene-G<；sub>；5<；/sub>；-NH-R2, phenylene-G<；sub>；6<；/sub>；-N(lower alkyl)-R2 or quinolinediyl-O-R2, the phenylene of said phenylene-cotnaining groups being optionally substituted with one or more substituents； G<；sub>；3<；/sub>；-R2 is -O-lower alkylene-R2 or the like； G<；sub>；4<；/sub>；-O- is lower alkylene-O- or the like； G<；sub>；5<；/sub>； is lower alkylene； G<；sub>；6<；/sub>； is lower alkylene].La presente invención proporciona un nuevo compuesto que tiene excelente efecto antitumoral. El compuesto de la presente invención se representa por la siguiente fórmula general (1) en donde R1 y R2 son arilo o similar； A es alquileno inferior, el anillo X es arileno opcionalmente sustituido, E es un enlace o alquenileno inferior； el anillo Y es heterocicloalquileno opcionalmente sustituido que contiene uno o más átomos de nitrógeno, uno de los cuales está unido al grupo carbonilo adyacente； G es -NH-N (alquilo inferior)-G2-, -NH-CH2-G2-, -N (alquilo inferior) -CH2-G2- o -CH2-G2-, [en donde G2 se une a R2, G2-R2 es enlace-R2, fenileno-G3-R2, fe
