DERIVES DE N-DEACETYLTHIOCOLCHICINE, LEUR UTILISATION ET FORMULATIONS PHARMACEUTIQUES LES CONTENANT

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专利权人:

INDENA S.P.A.

发明人:

BOMBARDELLI, EZIO,FONTANA, GABRIELE

申请号：

CA2555058

公开号：

CA2555058C

申请日:

2005.02.01

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

Disclosed is a series of N-deacetylthiocolchicine derivatives of formula (I)in which: - the linker is a bivalent straight or branched C1-C8 alkyl residue,C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring； - the G1 and G2junctions, which can be the same or different, are - CO-, -COHN-, -CR2- groupsin which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2group is the -CO- group. The compounds of formula (I) have antiproliferative,antinflammatory, antiarthritic and antiviral activity.

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