FAGET JULIEN,CAUX CHRISTOPHE,MENETRIER CAUX CHRISTINE,NUNES JACQUES,OLIVE DANIEL
申请号：
IN7256/CHENP/2013
公开号：
IN2013CN07256A
申请日:
2013.09.10
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL 10 and IFN production induce CD4+ T cells proliferation reduce Tconv proliferation and increase the immunosuppressive function of Treg.
