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ANTIBODIES DIRECTED AGAINST ICOS AND USES THEREOF
专利权人:
发明人:
FAGET JULIEN,CAUX CHRISTOPHE,MENETRIER CAUX CHRISTINE,NUNES JACQUES,OLIVE DANIEL
申请号:
IN7256/CHENP/2013
公开号:
IN2013CN07256A
申请日:
2013.09.10
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL 10 and IFN production induce CD4+ T cells proliferation reduce Tconv proliferation and increase the immunosuppressive function of Treg.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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