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OPHTHALMIC SOLUTION COMPRISING DIQUAFOSOL, METHOD FOR PRODUCING THE SAME, AND METHOD FOR INHIBITING FORMATION OF INSOLUBLE PRECIPITATE
专利权人:
LTD.;SANTEN PHARMACEUTICAL CO.
发明人:
AKIKO SAKATANI,TATSUO IKEI,KOJI INAGAKI,MASAKI SONODA,YOKO FUKUI,MITSUAKI KUWANO
申请号:
MYPI 2013002461
公开号:
MY161032A
申请日:
2011.12.27
申请国别(地区):
MY
年份:
2017
代理人:
摘要:
Regarding Diquafosol ophthalmic solution comprising a chelating agent, formation of insoluble precipitates found in Diquafosol ophthalmic solution during its storage, as well as deterioration of the filtration performance in the course of production (filtration sterilization), have been inhibited. Further, in Diquafosol ophthalmic solution comprising a chelating agent, enhancement of preservative effectiveness has been confirmed. Accordingly, the present invention provides Diquafosol ophthalmic solution having physicochemical properties that are stable during the courses of production and distribution as well as the course of storage by a patient. Particularly in the course of production, the solution can be subjected to efficient filtration sterilization. Moreover, the solution has excellent preservative effectiveness. The present invention also provides a method for inhibiting formation of insoluble precipitates from an aqueous ophthalmic solution comprising diquafosol or a salt thereof, by adding a chelating agent to the solution.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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