This invention relates to the use of a parenteral formulation comprising the NNRTI TMC278 for the long term prevention of HIV infection in a subject at risk of being infected by HIV, which comprises the intermittent administration of the said formulation at long time intervals.本發明係關於一包含NNRTI TMC278之非經腸胃調配物供一處於被感染HIV之危險中的個體用來長期預防HIV感染的用途,其係包含以長時間間隔間歇性地投予該調配物。