Mark Ian Fowler,Gail Jenkins,David James Messenger,Naila Rabbani,Paul John Thornalley,Mingzhan Xue
申请号：
US15775692
公开号：
US20180344603A1
申请日:
2016.11.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to a composition, in particular to an oral anti-ageing composition for treating hair ageing. This invention is based on the observation that the combination of hesperetin, a flavanone, derivable from a natural rutinoside hesperetin 7-rutinoside (also known as hesperidin) in citrus, e.g., in Citrus aurantium L, Citrus sinensis, Zanthozylum gilletti, leaves of Agathosma serratifolia, and trans-resveratrol synergistically up-regulates NQO-1 in a gene expression assay. The combination also induces Glo1, decreases MG and MG-protein glycation, decreases insulin resistance, decreases fasting plasma glucose, induces modest weight loss, improves renal function, decreases vascular inflammation marker slCAM-1, improves arterial dilatation and decreases the risk of cardiovascular disease. Thus is one aspect of the invention, a composition is provided, the composition comprising a combination of: (a) 30-10000, preferably 60-5000, most preferably 60-2500 mg in the form of an equivalent daily dose of flavanone of structure (I) wherein R is —H or —CH3, and mono-, di- and tri-acylated derivatives thereof； and (b) 20-1000, preferably 45-750, most preferably 45-500 mg in the form of an equivalent daily dose stilbenoid, wherein the composition comprises at least 0.5% w/w flavanone of structure I.
