通過利用二代核糖核酸結構幹擾在前信使核糖核酸中外顯子識別的調整作用

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专利权人:

ACADEMISCH ZIEKENHUIS LEIDEN

发明人:

VAN OMMEN, GARRIT-JAN, BOUDEWIJN,VAN DEUTEKOM, JUDITH, CHRISTINA, THEODORA,DEN DUNNEN, JOHANNES, THEODORUS,AARTSMA-RUS, ANNEMIEKE

申请号：

HK06107022.1

公开号：

HK1084694B

申请日:

2006.06.20

申请国别(地区):

HK

年份:

2014

代理人:

摘要：

The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for altering the secondary structure of an mRNA to interfere with splicing processes and uses of the oligonucleotides and methods in the treatment of disease. Further provided are pharmaceutical compositions and methods and means for inducing skipping of several exons in a pre-mRNA.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/