MALETINSKA, LENKA,ZELEZNA, BLANKA,BLECHOVA, MIROSLAVA,POPELOVA, ANDREA,MIKULASKOVA, BARBORA,KUNES, JAROSLAV
申请号：
CA2950416
公开号：
CA2950416A1
申请日:
2015.05.20
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention provides lipidated neuropeptides based on PrRP31, PrRP20, containing C14 and/or C16 fatty acid, wherein a sequence of IRPVGRF-NH2 at the C-terminus is variable in the site of isoleucine, valine and phenylalanine； said fatty acid is bound in position 1 or 11 for PrRP31 or its analog and in position 1 or 7 for PrRP20 or its analog； the fatty acid is bound directly or through a hydrophilic linker X2, for use in the treatment and prevention of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), cognitive impairment no dementia (CIND), brain trauma, and neurodegenerative changes and disorders.?
