lentiviral vector particle, pseudotyped lentiviral vector genome in an envelope, lentiviral vector packaging system for producing a pesudotyped lentiviral vector particle, cell, isolated nucleic acid molecule, expression vector, host cell, methods for making a particle of lentiviral vector, and to distribute lentiviral vector particles to invitro cells, and therapeutic or prophylactic vaccine
DEREK D. SLOAN,JAMES M. ALLEN,JIN ZHONG LI,NEAL S. VAN HOEVEN,THOMAS W. DUBENSKY JR
申请号：
BR112012001653
公开号：
BR112012001653A2
申请日:
2010.07.22
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant； and (b) a lentiviral vector genome comprising a sequence of interest； wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).
