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ПОЛИМОРФЫ И СОЛЬВАТЫ ГИДРОХЛОРИДА 4-[2-[[5-МЕТИЛ-1-(2-НАФТАЛИНИЛ)-1Н-ПИРАЗОЛ-3-ИЛ]ОКСИ]ЭТИЛ]МОРФОЛИНА
专利权人:
ЛАБОРАТОРЬОС ДЕЛЬ ДР. ЭСТЕВЕ; С.А. (ES)
发明人:
БЕРЕНГЕР МАЙМО Рамон (ES),МЕДРАНО РУПЕРЕС Хорхе (ES),БЕНЕТ БУХХОЛЬЦ Хорди (ES),ПУИГ ФЕРНАНДЕС Лаура (ES),ПЕЛЛЕХА ПУКСЕУ Лайа (ES)
申请号:
RU2012137495/04
公开号:
RU2012137495A
申请日:
2011.02.04
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A solid polymorphic or solvated form of the hydrochloride salt of 4- [2 - [[5-methyl-1- (2-naphthalenyl) -1H-pyrazol-3-yl] oxy] ethyl] morpholine. The solid form according to claim 1, selected from the group consisting of: a) a polymorphic form of phase I, characterized by a powder X-ray diffraction pattern showing characteristic peaks in the range of reflection angle [2θ in degrees] of about 5.9, 8.1, 11, 3, 11.7, 14.2, 15.1, 15.8, 16.3, 16.8, 17.8, 18.1, 18.6, 19.8, 20.9, 21.9, 22.8, 23.0, 23.2, 23.6, 23.9, 24.3, 25.0, 25.1, 28.0, 28.3, 28.6, 29.0, 29, 2, 30.7 and 30.9, b) a polymorphic form of phase II characterized by a powder X-ray diffraction pattern showing characteristic peaks in the range of reflection angle [2θ in degrees] of about 5.776, 11.629, 14.558, 15.737, 15.891, 16.420, 16.740, 17.441, 17.635, 18.056, 18.219, 19.232, 19.712, 20, 140, 20,685, 21,135, 21,889, 22,108, 22,478, 22,763, 23,219, 23,454, 23,782, 24,689, 25,065 and 25,671 c) a polymorphic form of phase III characterized by a powder X-ray diffraction pattern showing characteristic peaks in the reflection angle range [2θ in degrees ] about 5,437, 5,714, 10,918, 11,546, 12,704, 13,344, 13,984, 14,505, 15,606, 15,824, 16,164, 16,646, 17,333, 17,837, 18,719, 18,878, 19,236, 19,533, 20,142, 20,689, 21,337, 22,008, 22,929, 23,596, 24,748, 25,064, 25,207, 25,737 and 26,148 d) a polymorphic form of phase IV characterized by a powder X-ray diffraction pattern showing characteristic peaks in the range of reflection angle [2θ in degrees] n Approximately 5.805, 11.685, 15.559, 15.804, 16.397, 16.879, 17.357, 17.465, 17.621, 19.112, 19.435, 19.923, 21.224, 21.987, 22.167, 22.412, 22.852, 23.059, 23.359,1. Твердая полиморфная или сольватированная форма гидрохлоридной соли 4-[2-[[5-метил-1-(2-нафталинил)-1Н-пиразол-3-ил]окси]этил]морфолина.2. Твердая форма по п.1, выбранная из группы, состоящей из:а) полиморфной формы фазы I, характеризующейся порошковой рентгеновской дифрактограммой, демонстрирующей ха
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