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PREPARATIONS D'ACIDE DESOXYCHOLIQUE ET SELS ASSOCIES
专利权人:
INC.;KYTHERA BIOPHARMACEUTICALS
发明人:
HODGE, ROBERT EMIL,WEBSTER, JEFFREY DOUGLAS,MORIARTY, ROBERT M.
申请号:
CA2842177
公开号:
CA2842177A1
申请日:
2011.08.23
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.
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