NOUVEAUX CONJUGUES LIANT-PRINCIPE ACTIF (ADC) ET LEUR UTILISATION

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专利权人:

BAYER INTELLECTUAL PROPERTY GMBH;BAYER PHARMA AKTIENGESELLSCHAFT

发明人:

LERCHEN, HANS-GEORG,EL SHEIKH, SHERIF,BEIER, RUDOLF,BRUDER, SANDRA,STELTE-LUDWIG, BEATRIX,JORISSEN, HANNAH,MAHLERT, CHRISTOPH,GREVEN, SIMONE,PETRUL, HEIKE,SCHUHMACHER, JOACHIM,LINDEN, LARS,WILLUDA, JO

申请号：

CA2833690

公开号：

CA2833690A1

申请日:

2012.04.20

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The present application relates to novel, anti-Target Epidermal Growth Factor Receptor (EGFR, GeneID1956) binder-drug conjugates (ADCs) of N,N-dialkyl auristatins, to effective metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for treating and/or preventing diseases, and to the use of said ADCs for producing pharmaceuticals for treating and/or preventing diseases, in particular hyperproliferative and/or angiogenic diseases, such as cancers. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures.

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