152 112 162 7 --130 (116 133 132 X 110 160 ,--158 140 FIG. 2 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIP0 I PCT onion °nolo Oil 100TH 0010111 io 1111101 ow (10) International Publication Number WO 2018/164829 Al (51) International Patent Classification: A61M 5/14 (2006.01) A61115/142 (2006.01) A61M 5/158 (2006.01) (21) International Application Number: PCT/US2018/018687 (22) International Filing Date: 20 February 2018 (20.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/468,190 07 March 2017 (07.03.2017) US (71) Applicant: AMGEN INC. [US/US]； One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (US). (72) Inventor: MCCULLOUGH, Adam, B.； 2792 Great Smokey Court, Westlake Village, CA 91362 (US). (74) Agent: FURMANEK, Michael, P.； Marshall, Gerstein & Boron LLP, 233 S. Wacker Drive, 6300 Willis Tower, Chicago, IL 60606-6357 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: NEEDLE INSERTION BY OVERPRESSURE n 7 -126 co 00 O C (57) : An insertion mechanism for a drug delivery device. The insertion mechanism includes a proximal end, a distal end, a first opening disposed near the proximal end, and a second opening disposed in the distal end. A needle or cannula assembly is disposed within the housing and has
