A heart valve assembly includes a prosthesis for receiving a prosthetic valve to replace a preexisting natural or prosthetic heart valve within a biological annulus adjacent a sinus cavity. The prosthesis includes an annular member, a sewing cuff extending radially outwardly from the annular member and a plurality of guide rails extending from the prosthesis. The prosthetic valve includes an annular member, at least one valve and receptacles for receiving the guide rails. Locking tabs positioned on the guide rails engage with locking windows in the receptacles to attach the prosthetic valve with the prosthetic valve.
