STILGENBAUER STEPHAN,ZENZ THORSTEN,HEIDER KARL HEINZ
申请号：
IN504/DELNP/2013
公开号：
IN2013DN00504A
申请日:
2013.01.16
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention describes CD37 antibodies especially A2 and B2 for the treatment of patients with CLL especially of patients belonging to a "high risk" or "ultra high risk" group of patients. Those patients are either patients who are refractory to fludarabine treatment or patients who carry a genetic marker which is indicative for poor prognosis or increased risk of treatment failure e.g. patients with TP53 dysfunction or deletion of chromosome 17p13 or patients after failure to previous anti CD20 treatment. The ability of A2 and B2 to deplete CLL cells is high both in patient samples derived from patients with normal risk and with increased risk ("high risk" patients) and clearly superior to that of rituximab and alemtuzumab.
