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Fibronectin: growth factor chimeras
专利权人:
Zee Upton;Derek Van Lonkhuyzen
发明人:
Zee Upton,Derek Van Lonkhuyzen
申请号:
US13511776
公开号:
US09090706B2
申请日:
2010.11.30
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Isolated protein complexes are provided comprising growth factors such as IGF-I, IGF-II, EGF, bFGF, or KGF and fibronectin, or at least domains thereof that enable binding to and activation of both a growth factor receptor, and an integrin receptor-binding domain of fibronectin. These protein complexes include synthetic proteins where the growth factor and fibronectin sequences are joined by a linker sequence. Also provided are uses of these protein complexes for stimulating or inducing cell migration and/or proliferation in wound healing, tissue engineering, cosmetic and therapeutic treatments such as skin replacement, skin replenishment and treatment of burns where epithelial cell migration is required. In other embodiments, the invention provides inhibition of cancer cell metastasis, particularly in relation to breast cancer.
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