PASTERNAK, Alexander,SHAHRIPOUR, Aurash,TANG, Haifeng,TEUMELSAN, Nardos H.,YANG, Lihu,ZHU, Yuping,WALSH, Shawn P.
申请号：
ES10716982
公开号：
ES2561654T3
申请日:
2010.04.29
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound having structural Formula I: ** Formula ** or pharmaceutically acceptable salts thereof, in which: ** Formula ** represents a heterocyclic ring selected from the group consisting of: Z1 is selected from the group that consists of: ** Formula ** Z2 is selected from the group consisting of: ** Formula ** X is selected from the group consisting of -H, -OH, -O-C1-3 alkyl, -F, oxo , NH2 and -CH3； Y is selected from the group consisting of -H, -OH, -O-C1-3 alkyl, -F, oxo, NH2 and -CH3； X1 and Y1 are each independently selected from the group consisting of -H and -CH3； X2 and Y2 are each -O-； provided that when X is oxo then X1 is absent and when Y is oxo then Y1 is absent； and also provided that when neither X2 nor Y2 are present, then at least one of X and Y is selected from the group consisting of -OH, -O-C1-3alkyl, -F and oxo； R1 and R2 are each independently selected from the group consisting of -H, -halo, -C3-C6 cycloalkyl, -OR8, -SR8, -SOR8, -SO2R8, - (CH2) nOR8 and optionally substituted C1-C6 alkyl with 1-3 of -F； one of R3a and R3b is selected from the group consisting of -CN and -NO2 and the other is Re； one of R4a and R4b is selected from the group consisting of -CN and -NO2 and the other is Rf； R5 and R6 are each independently selected from the group consisting of -H, -C1-6 alkyl, -C3-6 cycloalkyl, -CF3, -CHF2, -CH2F and -CH2OH； R7 is selected from the group consisting of -H, -CH3, -CF3, -CHF2, -CH2F and -CH2OH； Ra and Rb are each independently selected from the group consisting of (a) -H, (b) halo, (c) -C1-6 alkyl optionally substituted with 1-3 of -F, (d) -C3 -cycloalkyl- 6, (e) -O-C1-3 alkyl optionally substituted with 1-3 of -F, (f) -OR8, (g) -CO2-C1-6 alkyl optionally substituted with 1-3 of -F, (h ) - (CH2) nOR8, (i) -SR8, (j) - SOR8, (k) -SO2R8, (l) -NHCOR8 and (m) -NHSO2R8； Rc and Rd are each independently selected from the group consisting of (a) -H, (b) halo, (c) -C1-6 alkyl optionally substituted with 1-3 of -F, (d) -C3 -cycloalkyl- 6, (e
