The present technique relates to an image processing apparatus, an image processing method, and a program that can easily execute a stitching process.Provided are: an image generation unit that generates a first reference image regarding a first imaging region on the basis of a plurality of first images regarding the first imaging region and that generates a second reference image regarding a second imaging region at least partially overlapping with the first imaging region on the basis of a plurality of second images regarding the second imaging region; and a processing unit that generates positioning information indicating a correspondence between the first imaging region and the second imaging region on the basis of the first reference image and the second reference image. The present technique can be applied to, for example, an image processing apparatus that executes a stitching process of a plurality of images.