The invention relates to hormone containing oil-in-water emulsion for parenteral administration comprising progestogen and/or estrogen a phospholipid comprising one or two omega-3 fatty acid moieties and an oil as well as a pharmaceutical composition comprising or consisting of said oil-in-water emulsion. The pharmaceutical is especially for use in the treatment or prophylaxis of neurological damage after strokes and/or trauma and/or for use in the treatment or prophylaxis of neurological damage after concussion and/or traumatic injury to the central nervous system.本發明係關於一種非經口投與之含有荷爾蒙的水包油型乳劑,其係包含助孕激素(progestogen)及/或雌性激素(estrogen)、包含一或二種ω-3脂肪酸部分的磷脂質、以及油;本發明亦關於一種醫藥組合物,其係包含前述之水包油型乳劑、或係由前述之水包油型乳劑所組成,該醫藥特別是用於治療或預防中風及/或創傷後之神經傷害,及/或用於治療或預防腦震盪後之神經傷害及/或中樞神經系統的創傷性損傷。