A method of producing an oral patch having a drug layer and an adhesive layer includes: filling a first layer powder that constitutes the drug layer in a mortar of a tableting machine； compressing the first layer powder at a tableting pressure of 0.2 kN to 1.2 kN to mold the drug layer； filling a second layer powder that constitutes the adhesive layer on the drug layer in the mortar； compressing the drug layer and the second layer powder at a tableting pressure of 6.0 kN to 26 kN to mold the adhesive layer； and compressing the drug layer and the adhesive layer at a tableting pressure of 7.5 kN to 26 kN.本發明之具備藥物層與附著層之口腔內貼附劑的製造方法，係將構成藥物層之第一層粉末填充於壓錠機的臼內，以0.2至1.2kN的壓錠壓力將第一層粉末壓縮以使藥物層成形，接著將構成附著層之第二層粉末填充於臼內的藥物層上，以6.0至26kN的壓錠壓力將藥物層及第二層粉末壓縮使附著層成形，然後以7.5至26kN的壓錠壓力將藥物層及附著層壓縮。
