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POLYPEPTIDE OR FUSED PROTEIN THEREOF INHIBITING THE EXTRAVASATION OF WHITE BLOOD CELLS OR THE GROWTH AND/OR METASTASIS OF CANCER CELLS
专利权人:
SUPADELIXIR INC.
发明人:
HAHN, JANG-HEE,LEE, KYOUNG-JIN,LEE, SUN-HEE,JU, HYUN-MI
申请号:
EP10825114
公开号:
EP2491944A4
申请日:
2010.08.24
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention relates to a polypeptide derived from a highly conserved region (HCR) I-III of an extracellular region of a CD99 and CD99 family such as CD99L2 and PBDX (or XG), which are a kind of transmembrane protein, or a fused protein thereof. The polypeptide or the fused protein thereof has an activating function of inhibiting the extravasation of white blood cells, or inhibiting the growth and/or metastasis of cancer cells. The present invention also provides a polynucleotide coding the polypeptide, a vector including same, and a transformant transformed by the vector. In addition, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof for preventing or treating inflammatory diseases. Further, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof inhibiting the growth and/or metastasis of cancer cells, i.e., a pharmaceutical composition for preventing or treating cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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