PROBLEM TO BE SOLVED: To provide a method of reducing a side effect caused by treating a disease or condition caused by or associated with hyperactive cholinergic innervation of muscles or exocrine glands in a patient.SOLUTION: The method is a method of administering a composition containing the neurotoxic component of a Clostridium botulinum toxin complex, the composition being devoid of any other protein component of the Clostridium botulinum toxin complex and being administered at short intervals and/or in high doses. The patient is a human, the composition is administered by injection, and the composition is administered at an interval of less than three months, the interval comprising first treatment and second treatment. The amount administered in the second treatment can be lower, higher or identical to the amount administered in the first treatment.【課題】患者の筋肉若しくは外分泌腺の活動亢進性コリン作動性神経支配を原因とするか又はそれに関連した疾患又は病状を治療するための副作用を軽減した方法の提供。【解決手段】他のタンパク質が全く無いボツリヌス菌毒素複合体の神経毒成分を含有する組成物を短い間隔で及び／又は高用量で投与する方法で、患者がヒトであり、組成物の投与が注射により行われるもので、第１の治療及び第２の治療を構成する３ヶ月未満の間隔で投与され、第２の治療で投与される量は、第１の治療で投与される量よりも低量、高量、又は同量であり得る方法。【選択図】なし
