Targeting chromatin regulators inhibits leukemogenic gene expression in NPM1 mutant leukemia

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专利权人:

Memorial Sloan-Kettering Cancer Center

发明人:

Armstrong, Scott A.

申请号：

AU2017212572

公开号：

AU2017212572A1

申请日:

2017.01.26

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

Disclosed are methods for inhibiting proliferation of or inducing apoptosis in certain leukemia cells or both. The methods comprise contacting a leukemia cell exhibiting an NPM1 mutation with a pharmacologic inhibitor of interaction between MLL and menin. More broadly, disclosed are methods for treating a susceptible leukemia using pharmacologic inhibition of Menin-MLL interaction. Also disclosed are methods for treating such leukemias using inhibition of Menin-MLL interaction in combination with DOT1L inhibition.

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中国工程科技知识中心

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